The Endocannabinoid System (ECS) is biological system composed of endocannabioids, which are neurotransmitters that bind to cannabinoid receptors, which are express throughout the central nervous system. The endocannabinoid system is involved in regulating a variety of physiological and cognitive processes including meditating the pharmacological effects of cannabis. The ECS is also involved in meditating some of the physiological and cognitive effects of voluntary physical exercise in humans and other animals, such as contributing to exercise-induced.
Two primary endocannabinoid receptors have been identified: CB1, first cloned in 1990; and CB2, cloned in 1993. CB1 receptors are found predominantly in the brain and nervous system, as well as in peripheral organs and tissues, and are the main molecular target of the phytocannabinoid THC. One other main endocannabinoid is 2-arachidonoyglycerol (2-AG) which is active at both cannabinoid receptors, along with its own phytocannabinoid, CBD. 2-AG and CBD are involved in the regulation of appetite, immune system functions and pain management.